FA-64256 / Medication dosing calculations / Open access
Order screening against mg/kg reference ranges: underdose tolerance · case 01
Doses slightly below the range are flagged as underdoses despite the tolerance.
ROOT CAUSE
The 10% tolerance is applied in the wrong direction (below 110% of lo instead of 90%).
THE FAILURE
The 10% tolerance is applied in the wrong direction (below 110% of lo instead of 90%).
Unsuccessful approach: Dropping the tolerance flags every dose below lo.
Case contract
Input {dose_mg, weight_kg (or null), age_days, range [lo, hi] mg/kg, optional neonatal_range, abs_max_mg}. Missing weight returns NO_WEIGHT. A dose above abs_max_mg returns OVER_ABSOLUTE. Neonates (age_days < 28) use neonatal_range when present. Toy 10% tolerance: UNDER when mg/kg < 0.9*lo, OVER when mg/kg > 1.1*hi, else OK. Return {flag, mg_per_kg (2 dp)}.
Why this case matters
Clinical decision support screens orders against weight-based ranges; the population gate and the tolerance edges are separate rules.
1 / The failure
Exit 1"""Failure Map reference implementation. Python standard library only."""
import json
import math
from fractions import Fraction
N = 1
observations = []
def solve(x):
if x['weight_kg'] is None:
return {'flag': 'NO_WEIGHT'}
dose = Fraction(str(x['dose_mg']))
if dose > x['abs_max_mg']:
return {'flag': 'OVER_ABSOLUTE'}
lo, hi = x['range']
if x['age_days'] < 28 and x.get('neonatal_range'):
lo, hi = x['neonatal_range']
per_kg = dose / Fraction(str(x['weight_kg']))
if per_kg * 10 < Fraction(str(lo)) * 11:
flag = 'UNDER'
elif per_kg * 10 > Fraction(str(hi)) * 11:
flag = 'OVER'
else:
flag = 'OK'
return {'flag': flag, 'mg_per_kg': round(float(per_kg), 2)}
def check(label, actual, expected):
observations.append({"check": label, "actual": actual, "expected": expected, "passed": actual == expected})
fixtures = [[('within range control',
{'dose_mg': 310, 'weight_kg': 20, 'age_days': 2000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 15.5}),
('neonate on day 27',
{'dose_mg': 13,
'weight_kg': 3,
'age_days': 27,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 4.33}),
('infant on day 28 uses standard range',
{'dose_mg': 13,
'weight_kg': 3,
'age_days': 28,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'UNDER', 'mg_per_kg': 4.33}),
('older infant ignores neonatal range',
{'dose_mg': 40,
'weight_kg': 4,
'age_days': 91,
'range': [8, 12],
'neonatal_range': [2, 4],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 10.0}),
('underdose within tolerance',
{'dose_mg': 91, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 9.1}),
('clear underdose',
{'dose_mg': 79, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'UNDER', 'mg_per_kg': 7.9}),
('overdose tolerance edge',
{'dose_mg': 242, 'weight_kg': 11, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 22.0}),
('dose exactly at absolute maximum',
{'dose_mg': 1000, 'weight_kg': 65, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 15.38}),
('absolute maximum',
{'dose_mg': 1060, 'weight_kg': 60, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OVER_ABSOLUTE'}),
('missing weight',
{'dose_mg': 100, 'weight_kg': None, 'age_days': 100, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'NO_WEIGHT'})],
[('within range control',
{'dose_mg': 320, 'weight_kg': 20, 'age_days': 2000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 16.0}),
('neonate on day 27',
{'dose_mg': 14,
'weight_kg': 3,
'age_days': 27,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 4.67}),
('infant on day 28 uses standard range',
{'dose_mg': 14,
'weight_kg': 3,
'age_days': 28,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'UNDER', 'mg_per_kg': 4.67}),
('older infant ignores neonatal range',
{'dose_mg': 40,
'weight_kg': 4,
'age_days': 92,
'range': [8, 12],
'neonatal_range': [2, 4],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 10.0}),
('underdose within tolerance',
{'dose_mg': 92, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 9.2}),
('clear underdose',
{'dose_mg': 78, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'UNDER', 'mg_per_kg': 7.8}),
('overdose tolerance edge',
{'dose_mg': 264, 'weight_kg': 12, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 22.0}),
('dose exactly at absolute maximum',
{'dose_mg': 1000, 'weight_kg': 70, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 14.29}),
('absolute maximum',
{'dose_mg': 1070, 'weight_kg': 60, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OVER_ABSOLUTE'}),
('missing weight',
{'dose_mg': 100, 'weight_kg': None, 'age_days': 200, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'NO_WEIGHT'})],
[('within range control',
{'dose_mg': 330, 'weight_kg': 20, 'age_days': 2000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 16.5}),
('neonate on day 27',
{'dose_mg': 15,
'weight_kg': 3,
'age_days': 27,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 5.0}),
('infant on day 28 uses standard range',
{'dose_mg': 15,
'weight_kg': 3,
'age_days': 28,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'UNDER', 'mg_per_kg': 5.0}),
('older infant ignores neonatal range',
{'dose_mg': 40,
'weight_kg': 4,
'age_days': 93,
'range': [8, 12],
'neonatal_range': [2, 4],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 10.0}),
('underdose within tolerance',
{'dose_mg': 93, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 9.3}),
('clear underdose',
{'dose_mg': 77, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'UNDER', 'mg_per_kg': 7.7}),
('overdose tolerance edge',
{'dose_mg': 286, 'weight_kg': 13, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 22.0}),
('dose exactly at absolute maximum',
{'dose_mg': 1000, 'weight_kg': 75, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 13.33}),
('absolute maximum',
{'dose_mg': 1080, 'weight_kg': 60, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OVER_ABSOLUTE'}),
('missing weight',
{'dose_mg': 100, 'weight_kg': None, 'age_days': 300, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'NO_WEIGHT'})],
[('within range control',
{'dose_mg': 340, 'weight_kg': 20, 'age_days': 2000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 17.0}),
('neonate on day 27',
{'dose_mg': 16,
'weight_kg': 3,
'age_days': 27,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 5.33}),
('infant on day 28 uses standard range',
{'dose_mg': 16,
'weight_kg': 3,
'age_days': 28,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'UNDER', 'mg_per_kg': 5.33}),
('older infant ignores neonatal range',
{'dose_mg': 40,
'weight_kg': 4,
'age_days': 94,
'range': [8, 12],
'neonatal_range': [2, 4],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 10.0}),
('underdose within tolerance',
{'dose_mg': 94, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 9.4}),
('clear underdose',
{'dose_mg': 76, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'UNDER', 'mg_per_kg': 7.6}),
('overdose tolerance edge',
{'dose_mg': 308, 'weight_kg': 14, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 22.0}),
('dose exactly at absolute maximum',
{'dose_mg': 1000, 'weight_kg': 80, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 12.5}),
('absolute maximum',
{'dose_mg': 1090, 'weight_kg': 60, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OVER_ABSOLUTE'}),
('missing weight',
{'dose_mg': 100, 'weight_kg': None, 'age_days': 400, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'NO_WEIGHT'})],
[('within range control',
{'dose_mg': 350, 'weight_kg': 20, 'age_days': 2000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 17.5}),
('neonate on day 27',
{'dose_mg': 17,
'weight_kg': 3,
'age_days': 27,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'OVER', 'mg_per_kg': 5.67}),
('infant on day 28 uses standard range',
{'dose_mg': 17,
'weight_kg': 3,
'age_days': 28,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'UNDER', 'mg_per_kg': 5.67}),
('older infant ignores neonatal range',
{'dose_mg': 40,
'weight_kg': 4,
'age_days': 95,
'range': [8, 12],
'neonatal_range': [2, 4],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 10.0}),
('underdose within tolerance',
{'dose_mg': 95, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 9.5}),
('clear underdose',
{'dose_mg': 75, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'UNDER', 'mg_per_kg': 7.5}),
('overdose tolerance edge',
{'dose_mg': 330, 'weight_kg': 15, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 22.0}),
('dose exactly at absolute maximum',
{'dose_mg': 1000, 'weight_kg': 85, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 11.76}),
('absolute maximum',
{'dose_mg': 1100, 'weight_kg': 60, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OVER_ABSOLUTE'}),
('missing weight',
{'dose_mg': 100, 'weight_kg': None, 'age_days': 500, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'NO_WEIGHT'})]]
for label, args, expected in fixtures[N-1]:
check(label, solve(args), expected)
print(json.dumps({"observations": observations, "passed": all(x["passed"] for x in observations)}, ensure_ascii=False))
raise SystemExit(0 if all(x["passed"] for x in observations) else 1)
| Boundary fixture | Actual | Expected | Outcome |
|---|---|---|---|
| within range control | {'flag': 'OK', 'mg_per_kg': 15.5} | {'flag': 'OK', 'mg_per_kg': 15.5} | Passed |
| neonate on day 27 | {'flag': 'OK', 'mg_per_kg': 4.33} | {'flag': 'OK', 'mg_per_kg': 4.33} | Passed |
| infant on day 28 uses standard range | {'flag': 'UNDER', 'mg_per_kg': 4.33} | {'flag': 'UNDER', 'mg_per_kg': 4.33} | Passed |
| older infant ignores neonatal range | {'flag': 'OK', 'mg_per_kg': 10.0} | {'flag': 'OK', 'mg_per_kg': 10.0} | Passed |
| underdose within tolerance | {'flag': 'UNDER', 'mg_per_kg': 9.1} | {'flag': 'OK', 'mg_per_kg': 9.1} | Failed |
| clear underdose | {'flag': 'UNDER', 'mg_per_kg': 7.9} | {'flag': 'UNDER', 'mg_per_kg': 7.9} | Passed |
| overdose tolerance edge | {'flag': 'OK', 'mg_per_kg': 22.0} | {'flag': 'OK', 'mg_per_kg': 22.0} | Passed |
| dose exactly at absolute maximum | {'flag': 'OK', 'mg_per_kg': 15.38} | {'flag': 'OK', 'mg_per_kg': 15.38} | Passed |
| absolute maximum | {'flag': 'OVER_ABSOLUTE'} | {'flag': 'OVER_ABSOLUTE'} | Passed |
| missing weight | {'flag': 'NO_WEIGHT'} | {'flag': 'NO_WEIGHT'} | Passed |
SHA-256 / 354e73349c1a7fc307a874e0ed65050b52158961440650cfc957f9451fb171a1
2 / The unsuccessful fix
Exit 1"""Failure Map reference implementation. Python standard library only."""
import json
import math
from fractions import Fraction
N = 1
observations = []
def solve(x):
if x['weight_kg'] is None:
return {'flag': 'NO_WEIGHT'}
dose = Fraction(str(x['dose_mg']))
if dose > x['abs_max_mg']:
return {'flag': 'OVER_ABSOLUTE'}
lo, hi = x['range']
if x['age_days'] < 28 and x.get('neonatal_range'):
lo, hi = x['neonatal_range']
per_kg = dose / Fraction(str(x['weight_kg']))
if per_kg < Fraction(str(lo)):
flag = 'UNDER'
elif per_kg * 10 > Fraction(str(hi)) * 11:
flag = 'OVER'
else:
flag = 'OK'
return {'flag': flag, 'mg_per_kg': round(float(per_kg), 2)}
def check(label, actual, expected):
observations.append({"check": label, "actual": actual, "expected": expected, "passed": actual == expected})
fixtures = [[('within range control',
{'dose_mg': 310, 'weight_kg': 20, 'age_days': 2000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 15.5}),
('neonate on day 27',
{'dose_mg': 13,
'weight_kg': 3,
'age_days': 27,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 4.33}),
('infant on day 28 uses standard range',
{'dose_mg': 13,
'weight_kg': 3,
'age_days': 28,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'UNDER', 'mg_per_kg': 4.33}),
('older infant ignores neonatal range',
{'dose_mg': 40,
'weight_kg': 4,
'age_days': 91,
'range': [8, 12],
'neonatal_range': [2, 4],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 10.0}),
('underdose within tolerance',
{'dose_mg': 91, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 9.1}),
('clear underdose',
{'dose_mg': 79, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'UNDER', 'mg_per_kg': 7.9}),
('overdose tolerance edge',
{'dose_mg': 242, 'weight_kg': 11, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 22.0}),
('dose exactly at absolute maximum',
{'dose_mg': 1000, 'weight_kg': 65, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 15.38}),
('absolute maximum',
{'dose_mg': 1060, 'weight_kg': 60, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OVER_ABSOLUTE'}),
('missing weight',
{'dose_mg': 100, 'weight_kg': None, 'age_days': 100, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'NO_WEIGHT'})],
[('within range control',
{'dose_mg': 320, 'weight_kg': 20, 'age_days': 2000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 16.0}),
('neonate on day 27',
{'dose_mg': 14,
'weight_kg': 3,
'age_days': 27,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 4.67}),
('infant on day 28 uses standard range',
{'dose_mg': 14,
'weight_kg': 3,
'age_days': 28,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'UNDER', 'mg_per_kg': 4.67}),
('older infant ignores neonatal range',
{'dose_mg': 40,
'weight_kg': 4,
'age_days': 92,
'range': [8, 12],
'neonatal_range': [2, 4],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 10.0}),
('underdose within tolerance',
{'dose_mg': 92, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 9.2}),
('clear underdose',
{'dose_mg': 78, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'UNDER', 'mg_per_kg': 7.8}),
('overdose tolerance edge',
{'dose_mg': 264, 'weight_kg': 12, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 22.0}),
('dose exactly at absolute maximum',
{'dose_mg': 1000, 'weight_kg': 70, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 14.29}),
('absolute maximum',
{'dose_mg': 1070, 'weight_kg': 60, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OVER_ABSOLUTE'}),
('missing weight',
{'dose_mg': 100, 'weight_kg': None, 'age_days': 200, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'NO_WEIGHT'})],
[('within range control',
{'dose_mg': 330, 'weight_kg': 20, 'age_days': 2000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 16.5}),
('neonate on day 27',
{'dose_mg': 15,
'weight_kg': 3,
'age_days': 27,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 5.0}),
('infant on day 28 uses standard range',
{'dose_mg': 15,
'weight_kg': 3,
'age_days': 28,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'UNDER', 'mg_per_kg': 5.0}),
('older infant ignores neonatal range',
{'dose_mg': 40,
'weight_kg': 4,
'age_days': 93,
'range': [8, 12],
'neonatal_range': [2, 4],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 10.0}),
('underdose within tolerance',
{'dose_mg': 93, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 9.3}),
('clear underdose',
{'dose_mg': 77, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'UNDER', 'mg_per_kg': 7.7}),
('overdose tolerance edge',
{'dose_mg': 286, 'weight_kg': 13, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 22.0}),
('dose exactly at absolute maximum',
{'dose_mg': 1000, 'weight_kg': 75, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 13.33}),
('absolute maximum',
{'dose_mg': 1080, 'weight_kg': 60, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OVER_ABSOLUTE'}),
('missing weight',
{'dose_mg': 100, 'weight_kg': None, 'age_days': 300, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'NO_WEIGHT'})],
[('within range control',
{'dose_mg': 340, 'weight_kg': 20, 'age_days': 2000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 17.0}),
('neonate on day 27',
{'dose_mg': 16,
'weight_kg': 3,
'age_days': 27,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 5.33}),
('infant on day 28 uses standard range',
{'dose_mg': 16,
'weight_kg': 3,
'age_days': 28,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'UNDER', 'mg_per_kg': 5.33}),
('older infant ignores neonatal range',
{'dose_mg': 40,
'weight_kg': 4,
'age_days': 94,
'range': [8, 12],
'neonatal_range': [2, 4],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 10.0}),
('underdose within tolerance',
{'dose_mg': 94, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 9.4}),
('clear underdose',
{'dose_mg': 76, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'UNDER', 'mg_per_kg': 7.6}),
('overdose tolerance edge',
{'dose_mg': 308, 'weight_kg': 14, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 22.0}),
('dose exactly at absolute maximum',
{'dose_mg': 1000, 'weight_kg': 80, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 12.5}),
('absolute maximum',
{'dose_mg': 1090, 'weight_kg': 60, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OVER_ABSOLUTE'}),
('missing weight',
{'dose_mg': 100, 'weight_kg': None, 'age_days': 400, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'NO_WEIGHT'})],
[('within range control',
{'dose_mg': 350, 'weight_kg': 20, 'age_days': 2000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 17.5}),
('neonate on day 27',
{'dose_mg': 17,
'weight_kg': 3,
'age_days': 27,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'OVER', 'mg_per_kg': 5.67}),
('infant on day 28 uses standard range',
{'dose_mg': 17,
'weight_kg': 3,
'age_days': 28,
'range': [10, 20],
'neonatal_range': [3, 5],
'abs_max_mg': 100},
{'flag': 'UNDER', 'mg_per_kg': 5.67}),
('older infant ignores neonatal range',
{'dose_mg': 40,
'weight_kg': 4,
'age_days': 95,
'range': [8, 12],
'neonatal_range': [2, 4],
'abs_max_mg': 100},
{'flag': 'OK', 'mg_per_kg': 10.0}),
('underdose within tolerance',
{'dose_mg': 95, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 9.5}),
('clear underdose',
{'dose_mg': 75, 'weight_kg': 10, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'UNDER', 'mg_per_kg': 7.5}),
('overdose tolerance edge',
{'dose_mg': 330, 'weight_kg': 15, 'age_days': 1000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 22.0}),
('dose exactly at absolute maximum',
{'dose_mg': 1000, 'weight_kg': 85, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OK', 'mg_per_kg': 11.76}),
('absolute maximum',
{'dose_mg': 1100, 'weight_kg': 60, 'age_days': 9000, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'OVER_ABSOLUTE'}),
('missing weight',
{'dose_mg': 100, 'weight_kg': None, 'age_days': 500, 'range': [10, 20], 'abs_max_mg': 1000},
{'flag': 'NO_WEIGHT'})]]
for label, args, expected in fixtures[N-1]:
check(label, solve(args), expected)
print(json.dumps({"observations": observations, "passed": all(x["passed"] for x in observations)}, ensure_ascii=False))
raise SystemExit(0 if all(x["passed"] for x in observations) else 1)
| Boundary fixture | Actual | Expected | Outcome |
|---|---|---|---|
| within range control | {'flag': 'OK', 'mg_per_kg': 15.5} | {'flag': 'OK', 'mg_per_kg': 15.5} | Passed |
| neonate on day 27 | {'flag': 'OK', 'mg_per_kg': 4.33} | {'flag': 'OK', 'mg_per_kg': 4.33} | Passed |
| infant on day 28 uses standard range | {'flag': 'UNDER', 'mg_per_kg': 4.33} | {'flag': 'UNDER', 'mg_per_kg': 4.33} | Passed |
| older infant ignores neonatal range | {'flag': 'OK', 'mg_per_kg': 10.0} | {'flag': 'OK', 'mg_per_kg': 10.0} | Passed |
| underdose within tolerance | {'flag': 'UNDER', 'mg_per_kg': 9.1} | {'flag': 'OK', 'mg_per_kg': 9.1} | Failed |
| clear underdose | {'flag': 'UNDER', 'mg_per_kg': 7.9} | {'flag': 'UNDER', 'mg_per_kg': 7.9} | Passed |
| overdose tolerance edge | {'flag': 'OK', 'mg_per_kg': 22.0} | {'flag': 'OK', 'mg_per_kg': 22.0} | Passed |
| dose exactly at absolute maximum | {'flag': 'OK', 'mg_per_kg': 15.38} | {'flag': 'OK', 'mg_per_kg': 15.38} | Passed |
| absolute maximum | {'flag': 'OVER_ABSOLUTE'} | {'flag': 'OVER_ABSOLUTE'} | Passed |
| missing weight | {'flag': 'NO_WEIGHT'} | {'flag': 'NO_WEIGHT'} | Passed |
SHA-256 / d5f8f1511d170137bed7f99217ebee2b522484fb4ad782607fe0e97401b7795e
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This mechanism has 10 recorded checks per implementation. The open-access tier publishes the failure and the unsuccessful fix; the repaired source that passes every check, and the observations that prove it, are available to members.
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Sign in to the archive ↗Verification & scope
A deterministic toy software model with explicitly stipulated thresholds and formulas; it is not clinical guidance, not a validated medical calculator, and makes no claim of conformance to any published protocol. Numbered variants vary patient and order inputs. This reproducer isolates one failure mechanism. Results cover the supplied fixtures. Variants within a family share a test contract and should remain grouped when constructing evaluation splits. Related mechanisms with a shared evaluation_group must also remain together; these controlled models are not independent production incidents.
Observations recorded using Python 3.12.14 at 2026-09-29T14:47:22.608271+00:00.
Case digest / 4064a62e05db3b432f38173fc92a3e00f5e68e17909da6ed8d689f3e0ab691ab