{"abstract":"Oral maintenance doses are smaller than the intravenous equivalent.","category":"Medication dosing calculations","checks":6,"contract":"Input {target, current, vd_l_kg, weight_kg, f, cl_ml_min, tau_h, unit_mg}. Toy one-compartment rule: loading = max(0, (target-current)*Vd*weight/F); maintenance = target*CL*tau/F with CL in L/h = cl_ml_min*60/1000. Both are rounded half-up to a multiple of unit_mg. Return {loading_mg, maintenance_mg}.","contract_signature":"x","evaluation_group":"w2-meddose-loading-maintenance","failed_approach":"Dropping F entirely treats an oral dose as if fully absorbed.","family":"w2-meddose-loading-maintenance-maintenance-bioavailability","id":"FA-64086","implementations":{"attempt":{"sha256":"c13036aa7a688e81111840804687b63d990ef891cecff787b3720f8af91271c2","source":"\"\"\"Failure Map reference implementation. Python standard library only.\"\"\"\nimport json\nimport math\nfrom fractions import Fraction\nN = 1\nobservations = []\ndef solve(x):\n    tgt, cur = Fraction(str(x['target'])), Fraction(str(x['current']))\n    f = Fraction(str(x['f']))\n    u = x['unit_mg']\n    vd = Fraction(str(x['vd_l_kg']))\n    wt = Fraction(str(x['weight_kg']))\n    cl = Fraction(x['cl_ml_min']) * 60 / 1000\n    def rnd(v):\n        return float(math.floor(v / u + Fraction(1, 2)) * u)\n    load = max(Fraction(0), (tgt - cur) * vd * wt / f)\n    maint = tgt * cl * x['tau_h']\n    return {'loading_mg': rnd(load), 'maintenance_mg': rnd(maint)}\ndef check(label, actual, expected):\n    observations.append({\"check\": label, \"actual\": actual, \"expected\": expected, \"passed\": actual == expected})\nfixtures = [[('drug-naive loading',\n   {'target': 15,\n    'current': 0,\n    'vd_l_kg': '0.7',\n    'weight_kg': 71,\n    'f': 1,\n    'cl_ml_min': 100,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 750.0, 'maintenance_mg': 1100.0}),\n  ('partial existing level credited',\n   {'target': 20,\n    'current': 6,\n    'vd_l_kg': '0.5',\n    'weight_kg': 80,\n    'f': '0.8',\n    'cl_ml_min': 80,\n    'tau_h': 8,\n    'unit_mg': 25},\n   {'loading_mg': 700.0, 'maintenance_mg': 950.0}),\n  ('level above target gives no load',\n   {'target': 10,\n    'current': 13,\n    'vd_l_kg': '0.6',\n    'weight_kg': 70,\n    'f': 1,\n    'cl_ml_min': 90,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 0.0, 'maintenance_mg': 650.0}),\n  ('oral bioavailability maintenance',\n   {'target': 2,\n    'current': 0,\n    'vd_l_kg': '1.0',\n    'weight_kg': 60,\n    'f': '0.5',\n    'cl_ml_min': 50,\n    'tau_h': 24,\n    'unit_mg': 5},\n   {'loading_mg': 240.0, 'maintenance_mg': 290.0}),\n  ('half unit rounds up',\n   {'target': 5,\n    'current': 0,\n    'vd_l_kg': '0.5',\n    'weight_kg': 65,\n    'f': 1,\n    'cl_ml_min': 25,\n    'tau_h': 6,\n    'unit_mg': 25},\n   {'loading_mg': 175.0, 'maintenance_mg': 50.0}),\n  ('slow clearance long interval',\n   {'target': 1,\n    'current': 0,\n    'vd_l_kg': '0.2',\n    'weight_kg': 50,\n    'f': 1,\n    'cl_ml_min': 10,\n    'tau_h': 24,\n    'unit_mg': 1},\n   {'loading_mg': 10.0, 'maintenance_mg': 14.0})],\n [('drug-naive loading',\n   {'target': 15,\n    'current': 0,\n    'vd_l_kg': '0.7',\n    'weight_kg': 72,\n    'f': 1,\n    'cl_ml_min': 100,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 750.0, 'maintenance_mg': 1100.0}),\n  ('partial existing level credited',\n   {'target': 20,\n    'current': 7,\n    'vd_l_kg': '0.5',\n    'weight_kg': 80,\n    'f': '0.8',\n    'cl_ml_min': 80,\n    'tau_h': 8,\n    'unit_mg': 25},\n   {'loading_mg': 650.0, 'maintenance_mg': 950.0}),\n  ('level above target gives no load',\n   {'target': 10,\n    'current': 14,\n    'vd_l_kg': '0.6',\n    'weight_kg': 70,\n    'f': 1,\n    'cl_ml_min': 90,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 0.0, 'maintenance_mg': 650.0}),\n  ('oral bioavailability maintenance',\n   {'target': 2,\n    'current': 0,\n    'vd_l_kg': '1.0',\n    'weight_kg': 60,\n    'f': '0.8',\n    'cl_ml_min': 50,\n    'tau_h': 24,\n    'unit_mg': 5},\n   {'loading_mg': 150.0, 'maintenance_mg': 180.0}),\n  ('half unit rounds up',\n   {'target': 5,\n    'current': 0,\n    'vd_l_kg': '0.5',\n    'weight_kg': 25,\n    'f': 1,\n    'cl_ml_min': 25,\n    'tau_h': 6,\n    'unit_mg': 25},\n   {'loading_mg': 75.0, 'maintenance_mg': 50.0}),\n  ('slow clearance long interval',\n   {'target': 1,\n    'current': 0,\n    'vd_l_kg': '0.2',\n    'weight_kg': 50,\n    'f': 1,\n    'cl_ml_min': 20,\n    'tau_h': 24,\n    'unit_mg': 1},\n   {'loading_mg': 10.0, 'maintenance_mg': 29.0})],\n [('drug-naive loading',\n   {'target': 15,\n    'current': 0,\n    'vd_l_kg': '0.7',\n    'weight_kg': 73,\n    'f': 1,\n    'cl_ml_min': 100,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 750.0, 'maintenance_mg': 1100.0}),\n  ('partial existing level credited',\n   {'target': 20,\n    'current': 8,\n    'vd_l_kg': '0.5',\n    'weight_kg': 80,\n    'f': '0.8',\n    'cl_ml_min': 80,\n    'tau_h': 8,\n    'unit_mg': 25},\n   {'loading_mg': 600.0, 'maintenance_mg': 950.0}),\n  ('level above target gives no load',\n   {'target': 10,\n    'current': 15,\n    'vd_l_kg': '0.6',\n    'weight_kg': 70,\n    'f': 1,\n    'cl_ml_min': 90,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 0.0, 'maintenance_mg': 650.0}),\n  ('oral bioavailability maintenance',\n   {'target': 2,\n    'current': 0,\n    'vd_l_kg': '1.0',\n    'weight_kg': 60,\n    'f': '0.25',\n    'cl_ml_min': 50,\n    'tau_h': 24,\n    'unit_mg': 5},\n   {'loading_mg': 480.0, 'maintenance_mg': 575.0}),\n  ('half unit rounds up',\n   {'target': 5,\n    'current': 0,\n    'vd_l_kg': '0.5',\n    'weight_kg': 45,\n    'f': 1,\n    'cl_ml_min': 25,\n    'tau_h': 6,\n    'unit_mg': 25},\n   {'loading_mg': 125.0, 'maintenance_mg': 50.0}),\n  ('slow clearance long interval',\n   {'target': 1,\n    'current': 0,\n    'vd_l_kg': '0.2',\n    'weight_kg': 50,\n    'f': 1,\n    'cl_ml_min': 30,\n    'tau_h': 24,\n    'unit_mg': 1},\n   {'loading_mg': 10.0, 'maintenance_mg': 43.0})],\n [('drug-naive loading',\n   {'target': 15,\n    'current': 0,\n    'vd_l_kg': '0.7',\n    'weight_kg': 74,\n    'f': 1,\n    'cl_ml_min': 100,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 800.0, 'maintenance_mg': 1100.0}),\n  ('partial existing level credited',\n   {'target': 20,\n    'current': 9,\n    'vd_l_kg': '0.5',\n    'weight_kg': 80,\n    'f': '0.8',\n    'cl_ml_min': 80,\n    'tau_h': 8,\n    'unit_mg': 25},\n   {'loading_mg': 550.0, 'maintenance_mg': 950.0}),\n  ('level above target gives no load',\n   {'target': 10,\n    'current': 16,\n    'vd_l_kg': '0.6',\n    'weight_kg': 70,\n    'f': 1,\n    'cl_ml_min': 90,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 0.0, 'maintenance_mg': 650.0}),\n  ('oral bioavailability maintenance',\n   {'target': 2,\n    'current': 0,\n    'vd_l_kg': '1.0',\n    'weight_kg': 60,\n    'f': '0.4',\n    'cl_ml_min': 50,\n    'tau_h': 24,\n    'unit_mg': 5},\n   {'loading_mg': 300.0, 'maintenance_mg': 360.0}),\n  ('half unit rounds up',\n   {'target': 5,\n    'current': 0,\n    'vd_l_kg': '0.5',\n    'weight_kg': 85,\n    'f': 1,\n    'cl_ml_min': 25,\n    'tau_h': 6,\n    'unit_mg': 25},\n   {'loading_mg': 225.0, 'maintenance_mg': 50.0}),\n  ('slow clearance long interval',\n   {'target': 1,\n    'current': 0,\n    'vd_l_kg': '0.2',\n    'weight_kg': 50,\n    'f': 1,\n    'cl_ml_min': 40,\n    'tau_h': 24,\n    'unit_mg': 1},\n   {'loading_mg': 10.0, 'maintenance_mg': 58.0})],\n [('drug-naive loading',\n   {'target': 15,\n    'current': 0,\n    'vd_l_kg': '0.7',\n    'weight_kg': 75,\n    'f': 1,\n    'cl_ml_min': 100,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 800.0, 'maintenance_mg': 1100.0}),\n  ('partial existing level credited',\n   {'target': 20,\n    'current': 10,\n    'vd_l_kg': '0.5',\n    'weight_kg': 80,\n    'f': '0.8',\n    'cl_ml_min': 80,\n    'tau_h': 8,\n    'unit_mg': 25},\n   {'loading_mg': 500.0, 'maintenance_mg': 950.0}),\n  ('level above target gives no load',\n   {'target': 10,\n    'current': 17,\n    'vd_l_kg': '0.6',\n    'weight_kg': 70,\n    'f': 1,\n    'cl_ml_min': 90,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 0.0, 'maintenance_mg': 650.0}),\n  ('oral bioavailability maintenance',\n   {'target': 2,\n    'current': 0,\n    'vd_l_kg': '1.0',\n    'weight_kg': 60,\n    'f': '0.6',\n    'cl_ml_min': 50,\n    'tau_h': 24,\n    'unit_mg': 5},\n   {'loading_mg': 200.0, 'maintenance_mg': 240.0}),\n  ('half unit rounds up',\n   {'target': 5,\n    'current': 0,\n    'vd_l_kg': '0.5',\n    'weight_kg': 105,\n    'f': 1,\n    'cl_ml_min': 25,\n    'tau_h': 6,\n    'unit_mg': 25},\n   {'loading_mg': 275.0, 'maintenance_mg': 50.0}),\n  ('slow clearance long interval',\n   {'target': 1,\n    'current': 0,\n    'vd_l_kg': '0.2',\n    'weight_kg': 50,\n    'f': 1,\n    'cl_ml_min': 50,\n    'tau_h': 24,\n    'unit_mg': 1},\n   {'loading_mg': 10.0, 'maintenance_mg': 72.0})]]\nfor label, args, expected in fixtures[N-1]:\n    check(label, solve(args), expected)\nprint(json.dumps({\"observations\": observations, \"passed\": all(x[\"passed\"] for x in observations)}, ensure_ascii=False))\nraise SystemExit(0 if all(x[\"passed\"] for x in observations) else 1)\n"},"broken":{"sha256":"c21e29b2b078bf4080ff396ae7334fbd8190c8218725cc2493b77c67664d4723","source":"\"\"\"Failure Map reference implementation. Python standard library only.\"\"\"\nimport json\nimport math\nfrom fractions import Fraction\nN = 1\nobservations = []\ndef solve(x):\n    tgt, cur = Fraction(str(x['target'])), Fraction(str(x['current']))\n    f = Fraction(str(x['f']))\n    u = x['unit_mg']\n    vd = Fraction(str(x['vd_l_kg']))\n    wt = Fraction(str(x['weight_kg']))\n    cl = Fraction(x['cl_ml_min']) * 60 / 1000\n    def rnd(v):\n        return float(math.floor(v / u + Fraction(1, 2)) * u)\n    load = max(Fraction(0), (tgt - cur) * vd * wt / f)\n    maint = tgt * cl * x['tau_h'] * f\n    return {'loading_mg': rnd(load), 'maintenance_mg': rnd(maint)}\ndef check(label, actual, expected):\n    observations.append({\"check\": label, \"actual\": actual, \"expected\": expected, \"passed\": actual == expected})\nfixtures = [[('drug-naive loading',\n   {'target': 15,\n    'current': 0,\n    'vd_l_kg': '0.7',\n    'weight_kg': 71,\n    'f': 1,\n    'cl_ml_min': 100,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 750.0, 'maintenance_mg': 1100.0}),\n  ('partial existing level credited',\n   {'target': 20,\n    'current': 6,\n    'vd_l_kg': '0.5',\n    'weight_kg': 80,\n    'f': '0.8',\n    'cl_ml_min': 80,\n    'tau_h': 8,\n    'unit_mg': 25},\n   {'loading_mg': 700.0, 'maintenance_mg': 950.0}),\n  ('level above target gives no load',\n   {'target': 10,\n    'current': 13,\n    'vd_l_kg': '0.6',\n    'weight_kg': 70,\n    'f': 1,\n    'cl_ml_min': 90,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 0.0, 'maintenance_mg': 650.0}),\n  ('oral bioavailability maintenance',\n   {'target': 2,\n    'current': 0,\n    'vd_l_kg': '1.0',\n    'weight_kg': 60,\n    'f': '0.5',\n    'cl_ml_min': 50,\n    'tau_h': 24,\n    'unit_mg': 5},\n   {'loading_mg': 240.0, 'maintenance_mg': 290.0}),\n  ('half unit rounds up',\n   {'target': 5,\n    'current': 0,\n    'vd_l_kg': '0.5',\n    'weight_kg': 65,\n    'f': 1,\n    'cl_ml_min': 25,\n    'tau_h': 6,\n    'unit_mg': 25},\n   {'loading_mg': 175.0, 'maintenance_mg': 50.0}),\n  ('slow clearance long interval',\n   {'target': 1,\n    'current': 0,\n    'vd_l_kg': '0.2',\n    'weight_kg': 50,\n    'f': 1,\n    'cl_ml_min': 10,\n    'tau_h': 24,\n    'unit_mg': 1},\n   {'loading_mg': 10.0, 'maintenance_mg': 14.0})],\n [('drug-naive loading',\n   {'target': 15,\n    'current': 0,\n    'vd_l_kg': '0.7',\n    'weight_kg': 72,\n    'f': 1,\n    'cl_ml_min': 100,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 750.0, 'maintenance_mg': 1100.0}),\n  ('partial existing level credited',\n   {'target': 20,\n    'current': 7,\n    'vd_l_kg': '0.5',\n    'weight_kg': 80,\n    'f': '0.8',\n    'cl_ml_min': 80,\n    'tau_h': 8,\n    'unit_mg': 25},\n   {'loading_mg': 650.0, 'maintenance_mg': 950.0}),\n  ('level above target gives no load',\n   {'target': 10,\n    'current': 14,\n    'vd_l_kg': '0.6',\n    'weight_kg': 70,\n    'f': 1,\n    'cl_ml_min': 90,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 0.0, 'maintenance_mg': 650.0}),\n  ('oral bioavailability maintenance',\n   {'target': 2,\n    'current': 0,\n    'vd_l_kg': '1.0',\n    'weight_kg': 60,\n    'f': '0.8',\n    'cl_ml_min': 50,\n    'tau_h': 24,\n    'unit_mg': 5},\n   {'loading_mg': 150.0, 'maintenance_mg': 180.0}),\n  ('half unit rounds up',\n   {'target': 5,\n    'current': 0,\n    'vd_l_kg': '0.5',\n    'weight_kg': 25,\n    'f': 1,\n    'cl_ml_min': 25,\n    'tau_h': 6,\n    'unit_mg': 25},\n   {'loading_mg': 75.0, 'maintenance_mg': 50.0}),\n  ('slow clearance long interval',\n   {'target': 1,\n    'current': 0,\n    'vd_l_kg': '0.2',\n    'weight_kg': 50,\n    'f': 1,\n    'cl_ml_min': 20,\n    'tau_h': 24,\n    'unit_mg': 1},\n   {'loading_mg': 10.0, 'maintenance_mg': 29.0})],\n [('drug-naive loading',\n   {'target': 15,\n    'current': 0,\n    'vd_l_kg': '0.7',\n    'weight_kg': 73,\n    'f': 1,\n    'cl_ml_min': 100,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 750.0, 'maintenance_mg': 1100.0}),\n  ('partial existing level credited',\n   {'target': 20,\n    'current': 8,\n    'vd_l_kg': '0.5',\n    'weight_kg': 80,\n    'f': '0.8',\n    'cl_ml_min': 80,\n    'tau_h': 8,\n    'unit_mg': 25},\n   {'loading_mg': 600.0, 'maintenance_mg': 950.0}),\n  ('level above target gives no load',\n   {'target': 10,\n    'current': 15,\n    'vd_l_kg': '0.6',\n    'weight_kg': 70,\n    'f': 1,\n    'cl_ml_min': 90,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 0.0, 'maintenance_mg': 650.0}),\n  ('oral bioavailability maintenance',\n   {'target': 2,\n    'current': 0,\n    'vd_l_kg': '1.0',\n    'weight_kg': 60,\n    'f': '0.25',\n    'cl_ml_min': 50,\n    'tau_h': 24,\n    'unit_mg': 5},\n   {'loading_mg': 480.0, 'maintenance_mg': 575.0}),\n  ('half unit rounds up',\n   {'target': 5,\n    'current': 0,\n    'vd_l_kg': '0.5',\n    'weight_kg': 45,\n    'f': 1,\n    'cl_ml_min': 25,\n    'tau_h': 6,\n    'unit_mg': 25},\n   {'loading_mg': 125.0, 'maintenance_mg': 50.0}),\n  ('slow clearance long interval',\n   {'target': 1,\n    'current': 0,\n    'vd_l_kg': '0.2',\n    'weight_kg': 50,\n    'f': 1,\n    'cl_ml_min': 30,\n    'tau_h': 24,\n    'unit_mg': 1},\n   {'loading_mg': 10.0, 'maintenance_mg': 43.0})],\n [('drug-naive loading',\n   {'target': 15,\n    'current': 0,\n    'vd_l_kg': '0.7',\n    'weight_kg': 74,\n    'f': 1,\n    'cl_ml_min': 100,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 800.0, 'maintenance_mg': 1100.0}),\n  ('partial existing level credited',\n   {'target': 20,\n    'current': 9,\n    'vd_l_kg': '0.5',\n    'weight_kg': 80,\n    'f': '0.8',\n    'cl_ml_min': 80,\n    'tau_h': 8,\n    'unit_mg': 25},\n   {'loading_mg': 550.0, 'maintenance_mg': 950.0}),\n  ('level above target gives no load',\n   {'target': 10,\n    'current': 16,\n    'vd_l_kg': '0.6',\n    'weight_kg': 70,\n    'f': 1,\n    'cl_ml_min': 90,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 0.0, 'maintenance_mg': 650.0}),\n  ('oral bioavailability maintenance',\n   {'target': 2,\n    'current': 0,\n    'vd_l_kg': '1.0',\n    'weight_kg': 60,\n    'f': '0.4',\n    'cl_ml_min': 50,\n    'tau_h': 24,\n    'unit_mg': 5},\n   {'loading_mg': 300.0, 'maintenance_mg': 360.0}),\n  ('half unit rounds up',\n   {'target': 5,\n    'current': 0,\n    'vd_l_kg': '0.5',\n    'weight_kg': 85,\n    'f': 1,\n    'cl_ml_min': 25,\n    'tau_h': 6,\n    'unit_mg': 25},\n   {'loading_mg': 225.0, 'maintenance_mg': 50.0}),\n  ('slow clearance long interval',\n   {'target': 1,\n    'current': 0,\n    'vd_l_kg': '0.2',\n    'weight_kg': 50,\n    'f': 1,\n    'cl_ml_min': 40,\n    'tau_h': 24,\n    'unit_mg': 1},\n   {'loading_mg': 10.0, 'maintenance_mg': 58.0})],\n [('drug-naive loading',\n   {'target': 15,\n    'current': 0,\n    'vd_l_kg': '0.7',\n    'weight_kg': 75,\n    'f': 1,\n    'cl_ml_min': 100,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 800.0, 'maintenance_mg': 1100.0}),\n  ('partial existing level credited',\n   {'target': 20,\n    'current': 10,\n    'vd_l_kg': '0.5',\n    'weight_kg': 80,\n    'f': '0.8',\n    'cl_ml_min': 80,\n    'tau_h': 8,\n    'unit_mg': 25},\n   {'loading_mg': 500.0, 'maintenance_mg': 950.0}),\n  ('level above target gives no load',\n   {'target': 10,\n    'current': 17,\n    'vd_l_kg': '0.6',\n    'weight_kg': 70,\n    'f': 1,\n    'cl_ml_min': 90,\n    'tau_h': 12,\n    'unit_mg': 50},\n   {'loading_mg': 0.0, 'maintenance_mg': 650.0}),\n  ('oral bioavailability maintenance',\n   {'target': 2,\n    'current': 0,\n    'vd_l_kg': '1.0',\n    'weight_kg': 60,\n    'f': '0.6',\n    'cl_ml_min': 50,\n    'tau_h': 24,\n    'unit_mg': 5},\n   {'loading_mg': 200.0, 'maintenance_mg': 240.0}),\n  ('half unit rounds up',\n   {'target': 5,\n    'current': 0,\n    'vd_l_kg': '0.5',\n    'weight_kg': 105,\n    'f': 1,\n    'cl_ml_min': 25,\n    'tau_h': 6,\n    'unit_mg': 25},\n   {'loading_mg': 275.0, 'maintenance_mg': 50.0}),\n  ('slow clearance long interval',\n   {'target': 1,\n    'current': 0,\n    'vd_l_kg': '0.2',\n    'weight_kg': 50,\n    'f': 1,\n    'cl_ml_min': 50,\n    'tau_h': 24,\n    'unit_mg': 1},\n   {'loading_mg': 10.0, 'maintenance_mg': 72.0})]]\nfor label, args, expected in fixtures[N-1]:\n    check(label, solve(args), expected)\nprint(json.dumps({\"observations\": observations, \"passed\": all(x[\"passed\"] for x in observations)}, ensure_ascii=False))\nraise SystemExit(0 if all(x[\"passed\"] for x in observations) else 1)\n"}},"limitations":"A deterministic toy software model with explicitly stipulated thresholds and formulas; it is not clinical guidance, not a validated medical calculator, and makes no claim of conformance to any published protocol. Numbered variants vary patient and order inputs. This reproducer isolates one failure mechanism. Results cover the supplied fixtures. Variants within a family share a test contract and should remain grouped when constructing evaluation splits. Related mechanisms with a shared evaluation_group must also remain together; these controlled models are not independent production incidents.","method":"Deterministic executable model with adversarial boundary fixtures.","provenance":{"created_by":"Failure Map","dependencies":"Python standard library","family":"w2-meddose-loading-maintenance-maintenance-bioavailability","generated_at":"2026-09-29T14:47:21.158131+00:00","license":"CC0-1.0","python":"3.12.14","seed":1,"split":"open-access"},"relevance":"Loading and maintenance calculations chain unit conversions and bioavailability; each factor is an independent defect site.","root_cause":"The maintenance dose multiplies by F instead of dividing by it.","sha256":"9705666a30306d2cc5a887ce5a586e701e9b74c7d2d6c4e1041d97cad31e1d25","title":"Pharmacokinetic loading and maintenance doses: maintenance bioavailability · case 01","variant":1,"variant_policy":"Five numbered records share a model and may reuse boundary fixtures.","verified":true,"visibility":"public","verification":{"attempt":{"elapsed_ms":42.736,"exit_code":1,"observations":[{"actual":{"loading_mg":750.0,"maintenance_mg":1100.0},"check":"drug-naive loading","expected":{"loading_mg":750.0,"maintenance_mg":1100.0},"passed":true},{"actual":{"loading_mg":700.0,"maintenance_mg":775.0},"check":"partial existing level credited","expected":{"loading_mg":700.0,"maintenance_mg":950.0},"passed":false},{"actual":{"loading_mg":0.0,"maintenance_mg":650.0},"check":"level above target gives no load","expected":{"loading_mg":0.0,"maintenance_mg":650.0},"passed":true},{"actual":{"loading_mg":240.0,"maintenance_mg":145.0},"check":"oral bioavailability maintenance","expected":{"loading_mg":240.0,"maintenance_mg":290.0},"passed":false},{"actual":{"loading_mg":175.0,"maintenance_mg":50.0},"check":"half unit rounds up","expected":{"loading_mg":175.0,"maintenance_mg":50.0},"passed":true},{"actual":{"loading_mg":10.0,"maintenance_mg":14.0},"check":"slow clearance long interval","expected":{"loading_mg":10.0,"maintenance_mg":14.0},"passed":true}],"passed":false,"stderr":"","stdout":"{\"observations\": [{\"check\": \"drug-naive loading\", \"actual\": {\"loading_mg\": 750.0, \"maintenance_mg\": 1100.0}, \"expected\": {\"loading_mg\": 750.0, \"maintenance_mg\": 1100.0}, \"passed\": true}, {\"check\": \"partial existing level credited\", \"actual\": {\"loading_mg\": 700.0, \"maintenance_mg\": 775.0}, \"expected\": {\"loading_mg\": 700.0, \"maintenance_mg\": 950.0}, \"passed\": false}, {\"check\": \"level above target gives no load\", \"actual\": {\"loading_mg\": 0.0, \"maintenance_mg\": 650.0}, \"expected\": {\"loading_mg\": 0.0, \"maintenance_mg\": 650.0}, \"passed\": true}, {\"check\": \"oral bioavailability maintenance\", \"actual\": {\"loading_mg\": 240.0, \"maintenance_mg\": 145.0}, \"expected\": {\"loading_mg\": 240.0, \"maintenance_mg\": 290.0}, \"passed\": false}, {\"check\": \"half unit rounds up\", \"actual\": {\"loading_mg\": 175.0, \"maintenance_mg\": 50.0}, \"expected\": {\"loading_mg\": 175.0, \"maintenance_mg\": 50.0}, \"passed\": true}, {\"check\": \"slow clearance long interval\", \"actual\": {\"loading_mg\": 10.0, \"maintenance_mg\": 14.0}, \"expected\": {\"loading_mg\": 10.0, \"maintenance_mg\": 14.0}, \"passed\": true}], \"passed\": false}\n"},"broken":{"elapsed_ms":44.273,"exit_code":1,"observations":[{"actual":{"loading_mg":750.0,"maintenance_mg":1100.0},"check":"drug-naive loading","expected":{"loading_mg":750.0,"maintenance_mg":1100.0},"passed":true},{"actual":{"loading_mg":700.0,"maintenance_mg":625.0},"check":"partial existing level credited","expected":{"loading_mg":700.0,"maintenance_mg":950.0},"passed":false},{"actual":{"loading_mg":0.0,"maintenance_mg":650.0},"check":"level above target gives no load","expected":{"loading_mg":0.0,"maintenance_mg":650.0},"passed":true},{"actual":{"loading_mg":240.0,"maintenance_mg":70.0},"check":"oral bioavailability maintenance","expected":{"loading_mg":240.0,"maintenance_mg":290.0},"passed":false},{"actual":{"loading_mg":175.0,"maintenance_mg":50.0},"check":"half unit rounds up","expected":{"loading_mg":175.0,"maintenance_mg":50.0},"passed":true},{"actual":{"loading_mg":10.0,"maintenance_mg":14.0},"check":"slow clearance long interval","expected":{"loading_mg":10.0,"maintenance_mg":14.0},"passed":true}],"passed":false,"stderr":"","stdout":"{\"observations\": [{\"check\": \"drug-naive loading\", \"actual\": {\"loading_mg\": 750.0, \"maintenance_mg\": 1100.0}, \"expected\": {\"loading_mg\": 750.0, \"maintenance_mg\": 1100.0}, \"passed\": true}, {\"check\": \"partial existing level credited\", \"actual\": {\"loading_mg\": 700.0, \"maintenance_mg\": 625.0}, \"expected\": {\"loading_mg\": 700.0, \"maintenance_mg\": 950.0}, \"passed\": false}, {\"check\": \"level above target gives no load\", \"actual\": {\"loading_mg\": 0.0, \"maintenance_mg\": 650.0}, \"expected\": {\"loading_mg\": 0.0, \"maintenance_mg\": 650.0}, \"passed\": true}, {\"check\": \"oral bioavailability maintenance\", \"actual\": {\"loading_mg\": 240.0, \"maintenance_mg\": 70.0}, \"expected\": {\"loading_mg\": 240.0, \"maintenance_mg\": 290.0}, \"passed\": false}, {\"check\": \"half unit rounds up\", \"actual\": {\"loading_mg\": 175.0, \"maintenance_mg\": 50.0}, \"expected\": {\"loading_mg\": 175.0, \"maintenance_mg\": 50.0}, \"passed\": true}, {\"check\": \"slow clearance long interval\", \"actual\": {\"loading_mg\": 10.0, \"maintenance_mg\": 14.0}, \"expected\": {\"loading_mg\": 10.0, \"maintenance_mg\": 14.0}, \"passed\": true}], \"passed\": false}\n"}},"member_only":{"stages":["fixed"],"fields":["implementations.fixed","verification.fixed","harness","repair"],"note":"The verified repair, its recorded checks, the repair description, and the scoring harness are available to members."}}